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KMID : 0363420090230030241
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Journal of Korean Oriental Pediatrics
2009 Volume.23 No. 3 p.241 ~ p.262
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The Effects of Jujadokseo-hwan on the Activation of Brain and Neuroprotactive Effects
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Lee Yu-Gyung
Chai Jung-Won
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Abstract
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Objectives: This study is designed to investigate the effects of Jujadokseo-hwan on the brain ability and inducing oxidative stresses.
Methods: We measured the changes of regional cerebral blood flow and mean arterial blood pressure. Then we analyzed histological examination, immunohistochemistric response and anti-oxidant activity of Jujadokseo-hwan.
Results: 1. Treatment of Jujadokseo-hwan significantly increased regional cerebral blood flow but decreased mean arterial blood pressure. 2. Treatment of Jujadokseo-hwan-induced increase of regional cerebral blood flow was significantly inhibited by pretreatment with indomethacin (1 mg/kg, i.p.), an inhibitor of cyclooxygenase. 3. In histological examination through TTC stain, group I was no change, but group II showed that discolored in the most cortical part. Group III showed that decreased discolor in the cortical part. 4. In immunohistochemistric response of BDNF, group II showed that lower response effect. Group III showed that increase response effect. 5. Treatment of Jujadokseo-hwan increased proliferation rates of Glial cell effectively 6. Treatment of Jujadokseo-hwan accelerated proliferation rates of C6 cells in vitro. In addition, protective effects on cell death induced by paraquat, rotenone and hydrogen peroxide. In addition, activity of SOD were increased by treatment with Jujadokseo-hwan.
Conclusions: In conclusion, Jujadokseo-hwan can improve of the brain ability, learning ability, memory ability and induce ischemic brain injuries.
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KEYWORD
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improvement of the brain ability, neuroprotactive effect, oxidate stress, Jujadokseo-hwan, brain function
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